Anything that could give rise to smarter-than-human intelligence - in the form of Artificial Intelligence, brain-computer interfaces, or neuroscience-based human intelligence enhancement - wins hands down beyond contest as doing the most to change the world. Nothing else is even in the same league.

A computer is a general-purpose machine with which we engage to do some of our deepest thinking and analyzing. This tool brings with it assumptions about structuredness, about defined interfaces being better. Computers abhor error.