The new millennium began with a great global dream. World leaders gathered at the United Nations in 2000 and adopted, among others, a historic goal to reduce poverty by half by 2015. Never in human history had such a bold goal been adopted by the entire world in one voice, one that specified time and size.

The genome was once thought to be just the blueprint for a living organism, like a combination of the architect's plan for a building and the builder's list of supplies. It specified the parts, the building blocks, and, somehow, the design of the whole, the way in which they are to be put together.

How will you know the difficulties of being human, if you are always flying off to blue perfection? Where will you plant your grief seeds? Workers need ground to scrape and hoe, not the sky of unspecified desire.

We can scarcely indeed look into any part of the sacred volume without meeting abundant proofs, that it is the religion of the Affections which God particularly requires. Love, Zeal, Gratitude, Joy, Hope, Trust, are each of them specified; and are not allowed to us as weaknesses, but enjoined on us as our bounden duty, and commended to us as our acceptable worship.

In fact, it was the religion of Calvin of which Sandy felt deprived, or rather a specified recognition of it. She desired this birthright; something definite to reject. It pervaded the place in proportion as it was unacknowledged. In some ways the most real and rooted people whom Sandy knew were Miss Gaunt and the Kerr sisters who made no evasions about their believe that Gold had planned for practically everybody before they were born an nasty surprise when they died. Later, when Sandy read John Calvin, she found that although popular conceptions of Calvinism were sometimes mistaken, in this particular there was no mistake, indeed it was but a mild understanding of the case, he having made it God's pleasure to implant in certain people an erroneous since of joy and salvation, so that their surprise at the end might be the nastier.

"There was only one catch and that was Catch-22, which specified that a concern for one's safety in the face of dangers that were real and immediate was the process of a rational mind. Orr was crazy and could be grounded. All he had to do was ask; and as soon as he did, he would no longer be crazy and would have to fly more missions. Orr would be crazy to fly more missions and sane if he didn't, but if he was sane he had to fly them. If he flew them he was crazy and didn't have to; but if he didn't want to he was sane and had to. Yossarian was moved very deeply by the absolute simplicity of this clause of Catch-22 and let out a respectful whistle.