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My 94-year-old grandmother has always been so inspiring to me. She is kind, smart, brave, and independent. After graduating number one in her medical school class at a time when it was extremely rare for women to attend medical school, she worked with the World Health Organization in North Africa to eradicate tuberculosis.

My mother was a nurse, and in her era, most diseases weren't understood; people put mustard plasters on knees and rubbed camphor on your chest if you had a cough and did funny things to you if you had tuberculosis - all these things that really made very little difference once proper treatments were brought in.

The biggest public health challenge is rebuilding health systems. In other words if you look at cholera or maternal mortality or tuberculosis in Haiti they're major problems in Haiti but the biggest problem is rebuilding systems.

We've taken on the major health problems of the poorest - tuberculosis maternal mortality AIDS malaria - in four countries. We've scored some victories in the sense that we've cured or treated thousands and changed the discourse about what is possible.

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