Racial humor was about 35% of my act when I first started. But I realized that it was a crutch. What brought it home was when another comedian said to me, 'If you changed color tomorrow, you wouldn't have any material.' He meant it as a put-down, but I took it as a challenge.

It used to take me forever to read and comprehend stuff, so I decided not to make the 'Captain Underpants' books too challenging. Don't get me wrong - the humor and ideas are often sophisticated - but the books aren't hard to read. I wanted kids who hate reading to find these books irresistible.

I regard the writing of humor as a supreme artistic challenge.

I've used my sense of humor as a coping tool. It's gotten me through a lot of challenging times.

In building a management team, I look for integrity, loyalty, vision, and a willingness to think outside of the box, and challenge the status quo. I also look for people who have a good sense of humor and who value and empower their team.

I was a prosecutor for 25 years. I saw so many 15, 16, even 20 year-olds who could not read, had little hope that they would ever find work, faced more challenges than opportunities in life, dropped out of school at some point, and turned to crime.

As CEO, I believe my most important job is to both define reality and inspire hope for the PayPal team. Defining reality includes being realistic about all the things that could go wrong so that we are prepared to navigate those challenges.

When we meet real tragedy in life, we can react in two ways - either by losing hope and falling into self-destructive habits, or by using the challenge to find our inner strength. Thanks to the teachings of Buddha, I have been able to take this second way.

My advice to young entrepreneurs is not to accept defeat in the face of odds, and challenge negative forces with hope, self-confidence and conviction.

One of the biggest challenges in my job is letting go of the movie once you go home at night, and knowing you can't do anything to your performance once you've laid it on film.

The challenges of delivering more housing so people can enjoy the benefits of home ownership and improving standards and choice in public services can also be met with a strong Conservative policy agenda.

Coming up with ideas isn't hard. The real challenge is finding the time to actually build something and then finding a home for it.

We are living in very challenging times. Pressured in the workplace and stressed out at home, people are trying to make sense of their lives.

Art is great. At its best, it engages the intellect and challenges the spirit; it connects us across history and reminds us of our humanity.

Despite its challenges, globalization has led to one of the most peaceful and productive times in world history.

History is made every day. The challenge is getting everyone to pay attention to it.

Investments in women are positively correlated to growth, prosperity, stability, democracy, health - and vital to our national security. We cannot write off the talent of half the world and expect to confront our challenges.

In terms of election issues, the urgent challenges we face include securing reforms to de-escalate the nuclear arms race, end voter suppression, improve health care for all Americans and alleviate the climate crisis.

By incarcerating someone who is homeless or addicted or who suffers from mental health challenges, we only further destabilize that person and create situations where they are more likely to commit crimes in the future.

There isn't a right or wrong way to be depressed, anxious, or struggle with PTSD. Mental health challenges manifest differently for different people, and it's important that people see that on-screen.

I really want you to recognize that if you're taking care of your physical and mental health, you can take on any challenge.

The Internet was appealing partly because it was something I could do in bed and feel like I was achieving something. I had an operation when I was 13 and ended up with complications, so I was in and out of the hospital. The bottom line is you can get through health challenges. It's part of why I was so driven.

Obviously, there is much similarity among the challenges of transgender people and all women - from health care to harassment to discrimination in the workplace.

Antibiotics are a very serious public health problem for us, and it's getting worse. Resistant microbes outstrip new antibiotics. It's an ongoing problem. It's not like we can fix it, and it's over. We have to fight continued resistance with a continual pipeline of new antibiotics and continue with the perpetual challenge.