The most significant barrier to female leadership is the actual lack of females in leadership. The best advice I can give to women is to go out and start something, ideally their own businesses. If you can't see a path for leadership within your own company, go blaze a trail of your own.

When we developed written language, we significantly increased our functional memory and our ability to share insights and knowledge across time and space. The same thing happened with the invention of the printing press, the telegraph, and the radio.

You can go online now and find really thoughtful, in-depth, considered, well-informed communities around virtually any issue. If it's your issue, there are now new ways of mobilising knowledge that weren't there before. There are real bodies of significant knowledge on the web that are valuable that we haven't done nearly enough with.

In this 21st century world, some of our country's most significant exports and imports extend beyond goods and services: They also include innovation, knowledge, discovery, and healing.

Thanks to postmodernism, we tend to see all facts as meaningless trivia, no one more vital than any other. Yet this disregard for facts qua facts is intellectually crippling. Facts are the raw material of thought, and the knowledge of significant facts makes sophisticated thought possible.

Even scientific knowledge, if there is anything to it, is not a random observation of random objects; for the critical objectivity of significant knowledge is attained as a practice only philosophically in inner action.

There's no question that as science, knowledge and technology advance, that we will attempt to do more significant things. And there's no question that we will always have to temper those things with ethics.

When the States already had nuclear weapons, and the Soviet Union was only building them, we got a significant amount of information through Soviet foreign intelligence channels.

George W. Bush attended the intelligence briefing every day. Obama has not even attended half of them. He sends surrogates. That to me is significant.

Advertising isn't just the disruption of aesthetics, the insults to your intelligence and the interruption of your train of thought. At every company that sells ads, a significant portion of their engineering team spends their day tuning data mining, writing better code to collect all your personal data.

The most significant moment in the course of intellectual development, which gives birth to the purely human forms of practical and abstract intelligence, occurs when speech and practical activity, two previously completely independent lines of development, converge.

We must address, individually and collectively, moral and ethical issues raised by cutting-edge research in artificial intelligence and biotechnology, which will enable significant life extension, designer babies, and memory extraction.

There can be no argument about the Lone Star State's significant contributions to American history, and we must remember the actions and the sacrifices of those who made Texas independence a reality.

As we explore ways to bring price relief and bolster our country's energy independence, one significant energy source has emerged as a potential solution, hydrogen fuel cells.

My country has contrived for me the most insignificant office that ever the invention of man contrived or his imagination conceived.

I don't have hard numbers about this, but the impression I get is that the amount of eyeballs you get from being on the humor shelf at Barnes & Noble - it is almost insignificant.

Humor is probably the most significant characteristics of the human mind. Far more significant than reason. In fact, reason is actually a very cheap commodity.

It has always surprised me how little attention philosophers have paid to humor, since it is a more significant process of mind than reason. Reason can only sort out perceptions, but the humor process is involved in changing them.

Humor is by far the most significant activity of the human brain.

I used to hear on the radio people like Jack Benny or Bob Hope, but I never had any interest in their type of humor. I thought that I could do something more substantially meaningful with significant, thoughtful, analytical reflections on real life situations.

The capacity for hope is the most significant fact of life. It provides human beings with a sense of destination and the energy to get started.

Nothing is insignificant in the history of a young community, and - above all - nothing seems impossible.

Every time I attend an FBI graduation for new agents or new analysts at Quantico, a significant number of those graduates are former state and local officers, and I have the privilege of shaking their hands, presenting them with their credentials, and welcoming them to the FBI family.

Graduation is an important day. It is a significant achievement.