A significant number of research studies have documented that heart disease is easily and almost completely preventable through a diet rich in plant produce and lower in processed foods and animal products.

Making changes in the fast food that makes up such a significant part of the American diet, even if the numbers aren't impressive, will have important health up sides.

While pimples are not as simple as too much milk or sugar in your diet, both have a significant impact. Nutritional deficiencies as well as excesses can worsen acne.

We believe that such a significant increase in longevity is due to the protective effect against cancer produced by caloric restriction - incidences fall by 40 percent if we compare them with the mice that produce more telomerase and have a normal diet - and, added to the presence of longer telomeres, this makes the mice live longer and better.

The new Zune may not be an iPod killer, but it does offer a clean interface, great industrial design, HD radio, and a subscription model for music, making it significantly less expensive for big users.

In any case, his judgment and set of values, acting alone or through his assistants, determine not only what is gold and what is dross but the design of the history which he creates out of the metal. The historian decides what is significant, and what is not.

I would urge everyone to start looking at the world in a different way. Spend some time looking at everyday objects, at their design, their shape, their individual characteristics. Think ahead and imagine their significance.

Let it be your constant method to look into the design of people's actions, and see what they would be at, as often as it is practicable; and to make this custom the more significant, practice it first upon yourself.

I'm much more interested in what an actor has to say about something substantial and important than who they're dating or what clothes they're wearing or some other asinine, insignificant aspect of their life.

The Google algorithm was a significant development. I've had thank-you emails from people whose lives have been saved by information on a medical website or who have found the love of their life on a dating website.

It seems essential, in relationships and all tasks, that we concentrate only on what is most significant and important.

Without white South Africa realizing what it had done - and on the basis of that realization having the courage to ask for forgiveness - there can really be no significant movement.

What's happened with society is that we have created these devices, computers, which already can register and process huge amounts of information, which is a significant fraction of the amount of information that human beings themselves, as a species, can process.

The digital revolution is far more significant than the invention of writing or even of printing.

Every major communication tool on the Internet has spam and abuse problems. All email services, blogging services and social networks have to dedicate a significant amount of resources and time to fighting abuse and protecting their users.

Significant officials at publicly traded companies are casually and cavalierly engaged in insider trading. Because insider trading has as one of its elements communication, it doesn't take rocket science to realize it's nice to have the communication on tape.

When we made 'Life in a Day,' we asked people around the globe to record their lives on a single ordinary day. When we were cutting that film, we talked about what it might be like if we chose a day that already had significance to people. The result is 'Christmas in a Day.'

Creating an overall healthy lifestyle for yourself doesn't require a radical diet or significant life change. In fact, it can be attained through common sense decisions about the way we eat, move, and live.

Being ready isn't enough; you have to be prepared for a promotion or any other significant change.

We must remember that one determined person can make a significant difference, and that a small group of determined people can change the course of history.

The specter of climate change threatens worsening natural disasters, rapid urbanization, forced migration, and economic hardship for the most vulnerable. Despite significant global advances, inability to effectively address epidemics and health emergencies still prevail and continuously threaten global health security and economic development.

Chance is hugely significant in biology. In fact, the presence of apparent randomness in so many aspects of biology - from mutations in DNA to the chance involved in that one sperm reaching that one egg that became you - suggests that randomness is useful, even necessary, in very many cases.

Coffee has always been a significant part of my life. For me, it's a chance to start my day and gather my thoughts - it's fuel for my creative process.

There's no chance that the iPhone is going to get any significant market share.